Sinna EA, Ezzat N. Knowledge on the burden of thyroid disease in Uganda is still limited. The section was dehydrated by increasing concentration of alcohol. While FNAC is the principal screening and triage procedure in the evaluation of palpable thyroid nodules, there is controversy as to whether this should be performed under ultrasound guidance or as a purely manual technique. Author contributions RM developed the concept, participated in data collection and manuscript writing, PKO participated in data collection, analysis, manuscript writing, JOF and DW reviewed the concept, data analysis and manuscript. Some features of this site may not work without it.
Conclusion This study reveals high specificity and a low sensitivity for FNAC at detecting malignancy in thyroid nodules. The main aim of FNAC is to identify nodules that require surgery and those benign nodules that can be observed clinically and decrease the overall thyroidectomy rate in patients with benign diseases. The main goal of evaluating these nodules is to identify nodules with malignant potential. Permanent link to OUR Archive version: Important factor for the satisfactory test includes representative specimen from the nodule and an experienced cytologist to interpret findings. FNAC is cost-effective, minimally invasive and highly accurate for investigating patients with thyroid cancer. This is in accordance with previous studies [ 7 , 13 ].
Backward and forward movements were used under constant suction with the needle moved at different depths and angles within the confines of the nodule. US Features of thyroid malignancy: All patients with clinically diagnosed solitary thyroid nodule who were clinically and biochemically euthyroid were included for study. Arch Pathol Lab Med.
This included both the classical and follicular variant. View at Google Scholar S. Fine needle aspiration cytology of thyroid nodules at Kenyatta National Hospital, Nairobi.
Distinct effects on splicing of two monoclonal antibodies directed against the amino-terminal domain of galectin Sixty cases of solitary thyroid nodules were included in the study. Just like other studies with a high prevalence of multinodular goiter, the sensitivity for detecting malignancy is relatively low where as tgesis is high thyroix For the retrospective arm, blinding of the histopathologist to the corresponding cytological diagnosis with FNAC may not have been observed.
The attending cytopathologist examined the smears for standard adequate amount of follicular cells for cytodiagnosis. The retrospective arm involved retrieving patients’ records cytological and histopathological reports from the pathology department of Makerere University College of Health Sciences MakCHS that had undergone thyroidectomy from January to December and the other arm involved prospective recruitment of patients from January to April Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions.
Duration of complaints ranged from six days to twenty years and mean duration was 1. The methods used for the calculation of sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were similar to previous studies [ 1112 ].
A multitude of diagnostic tests like ultrasound, thyroid nuclear scan, and fine needle aspiration cytology FNAC is available to the clinician for evaluation of thyroid nodule.
While FNAC is the principal screening and triage procedure in the evaluation of palpable thyroid nodules, there is controversy as to whether this should be performed under ultrasound guidance or as a purely manual fnax. Peroxidase-anti peroxidase immune complex method or the biotin-avidin immunoenzymatic technique is used. American Journal of Clinical Pathology.
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
Role of ultrasonography in the diagnosis and management of thyroid cancer. Duration of symptoms in weeks, Median IQR. Open in a separate window.
These can be improved partially by additional specific guidance and committed workshops on the use of Galectin-3 expression testing. Conclusion This study reveals high specificity and a low sensitivity for FNAC at detecting malignancy in thyroid nodules.
Specimens were processed in automated tissue processing units and staining was performed with routine haematoxylin and eosin stain. The purpose of this study was to estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology of excised specimen as a gold standard and to describe histopathological diagnoses of thyroid thesls in patients following thyroidectomy.
Journal of Thyroid Research
The negative predictive value in this study was We were unable to achieve the estimated sample size within the study period. These reporting schedules were least informative due to variability of sensitivity and least reproducibility.
The incidence of malignancy can be as high as The section was dehydrated by increasing concentration of alcohol. Diagnostic accuracy of fine needle aspiration cytology in thyroid lesions: AM is responsible and accountable for the accuracy or integrity of the work. The result is consistent with a study of Raggio et al.